What is Nitrazepam?
Nitrazepam belongs to the group of benzodiazepines. It is chemically known as 1,3-dihydro-2H-1.4-benzodiazepine-2-one. They are known by many names such as neozepam, Imeson, Mogadon, nelmat, etc. Nitrazepam has multiple effects on the organ system such as “calming effect” on the mind, induces sleep and improves sleep, reduces anxiety, and produces hypnotism. They also have muscle relaxant, anti-convulsant (fits), and sedative actions. Anxiolytics are a group of drugs that control the symptoms of anxiety, produce a restful state of mind without interfering with normal mental or physical functions. Adding to its anxiolytic actions, it is also a hypnotic or sleep-inducing drug. Nitrazepam induces and/or maintains normal arousable sleep. It is also used to treat insomnia. It relaxes the voluntary muscles by not causing any change to the functioning of the involuntary muscles. This means that actions such as breathing, digestion does not get affected by this drug and concomitantly relaxes the muscles of the limbs, spine, and others. It reduces the epileptic attacks immediately. Nitrazepam works very well in controlling seizures in infants. These are categorized as schedule IV drugs, which are available on a doctor’s prescription. Nitrazepam is also known to have a low potential for abuse and dependence.
How does it work?
Nitrazepam acts on a particular network system in the midbrain called “GABA-RECEPTOR CHLORINE CHANNEL COMPLEX” (gamma-aminobutyric acid (GABA), is an inhibitory neurotransmitter in the brain) which controls and maintains the ‘wakefulness” of the person and also the thought and mental functions. They also depress the central nervous system, by acting as a tranquilizer with an anti-epileptic, sedative, muscle relaxant, and amnestic properties. 5-10 mg is considered as the hypnotic dose and anxiolytic dose. It causes a drop in blood pressure due to a decrease in the pumping action of the heart. It causes muscle relation centrally by acting on all voluntary muscles and very minimally on involuntary muscles. Its hypnotic actions are brought about by fastening the onset of sleep, reducing intermittent awakening, and an increase in total sleep time.
What are the benefits of taking it?
It is a drug that has multiple actions that commonly end up producing a calming action and a state of clarity and freshness to the mind. It gives a sense of “light-headedness” and “happiness” though it’s not said to have euphoric effects. It is used extensively to treat short periods of insomnia, parasomnia, nightmares, and night terrors. It relaxes skeletal muscle spasms which occurs as a result of reflex muscle catches to local injures such as inflamed joints. Nitrazepam 5mg when given as an injection immediately brings into effect its anti-convulsant actions.it is also known to be given as a premedication drug before surgeries to calm a restless mind. Due to its low potential for abuse and dependence, these drugs when taken beyond 4 weeks are not fatal.
How should you take it?
They are available as tablets which are taken orally and injections which are administered by the physician. The tablets are available in blister packs of 28 and 56 tablets. Each blister strip contains 14 tablets. They must be stored below 25deg C and be protected from sunlight.
They are taken in the night before bedtime for the management of sleeping disorders such as insomnia, etc. For the management of anxiety and panic disorders, they are taken twice during the day. 5-10mg nitrazepam is the dosage for anxiety disorders and 5mg is the dosage for sleeping disorders if the patient is lactating, pregnant, or has kidney or liver problems the prescribing doctor must be informed.
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